In Central Denmark Region the RIS3 strategies are Growth drives and Smart industry; National/regional research and innovation strategies for smart specialization (RIS3) are integrated and place-based economic agendas for development which supports the following five key issues: 1)They focus on policy support and investments on key national/regional priorities, challenges and needs for knowledge-based development, including ICT-related measures; 2)They build on strengths, competitive advantages and potential for excellence in each region; 3)They support technological as well as practice-based innovation and aim to stimulate private sector investment; 4)They get stakeholders fully involved and encourage innovation and experimentation; 5)They are evidence-based and include evaluation systems. The Policy makers needs to strengthen the innovation in the public sector (e.g. hospitals), needs to do the Regional Innovation Strategy more visible for stakeholders and need to evaluate the regional innovation strategy to achieve improvement